Statistical estimation of a growth-fragmentation model observed on a genealogical tree
Résumé
We raise the issue of estimating the division rate for a growing and dividing population modelled by a piecewise deterministic Markov branching tree. Such models have broad applications, ranging from TCP/IP window size protocol to bacterial growth. Here, the individ-uals split into two offsprings at a division rate B(x) that depends on their size x, whereas their size grow exponentially in time, at a rate that exhibits variability. The mean empirical measure of the model satisfies a growth-fragmentation type equation, and we bridge the determinis-tic and probabilistic viewpoints. We then construct a nonparametric estimator of the division rate B(x) based on the observation of the pop-ulation over different sampling schemes of size n on the genealogical tree. Our estimator nearly achieves the rate n −s/(2s+1) in squared-loss error asymptotically, generalizing and improving on the rate n −s/(2s+3) obtained in [13, 15] through indirect observation schemes. Our method is consistently tested numerically and implemented on Escherichia coli data, which demonstrates its major interest for practical applications.
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