%0 Journal Article %T From a Sequential Chemo-Enzymatic Approach to a Continuous Process for HMF Production from Glucose %+ Institut Charles Viollette (ICV) - EA 7394 (ICV) %+ Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS) %+ IFP Energies nouvelles (IFPEN) %A Gimbernat, Alexandra %A Guehl, Marie %A Lopes Ferreira, Nicolas %A Heuson, Egon %A Dhulster, Pascal %A Capron, Mickaël %A Dumeignil, Franck %A Delcroix, Damien %A Girardon, Jean %A Froidevaux, Renato %Z This research was funded by IFP Energies nouvelles for funding these studies. Chevreul Institute (FR 2638), Ministère de l’Enseignement Supérieur et de la Recherche, Région Hauts-de-France (CPER ALIBIOTECH), REALCAT platform (‘Future Investments’ program (PIA), with the contractual reference ‘ANR-11-EQPX-0037′) and FEDER are acknowledged for supporting and funding partially this work. %< avec comité de lecture %@ 2073-4344 %J Catalysts %I MDPI %V 8 %N 8 %P 335 %8 2018-08 %D 2018 %R 10.3390/catal8080335 %K (bio)catalysis %K HMF %K chemo‐enzymatic catalysis %K (bio) catalysis %K biomass %K glucose %K 5-hydroxymethylfurfural (HMF) %K chemo-enzymatic catalysis %Z Chemical SciencesJournal articles %X Notably available from the cellulose contained in lignocellulosic biomass, glucose is a highly attractive substrate for eco-efficient processes towards high-value chemicals. A recent strategy for biomass valorization consists on combining biocatalysis and chemocatalysis to realise the so-called chemo-enzymatic or hybrid catalysis. Optimisation of the glucose conversion to 5-hydroxymethylfurfural (HMF) is the object of many research efforts. HMF can be produced by chemo-catalyzed fructose dehydration, while fructose can be selectively obtained from enzymatic glucose isomerization. Despite recent advances in HMF production, a fully integrated efficient process remains to be demonstrated. Our innovative approach consists on a continuous process involving enzymatic glucose isomerization, selective arylboronic-acid mediated fructose complexation/transportation, and chemical fructose dehydration to HMF. We designed a novel reactor based on two aqueous phases dynamically connected via an organic liquid membrane, which enabled substantial enhancement of glucose conversion (70%) while avoiding intermediate separation steps. Furthermore, in the as-combined steps, the use of an immobilized glucose isomerase and an acidic resin facilitates catalyst recycling %G English %2 https://ifp.hal.science/hal-01915536v2/document %2 https://ifp.hal.science/hal-01915536v2/file/catalysts-08-00335-v4.pdf %L hal-01915536 %U https://ifp.hal.science/hal-01915536 %~ UNIV-ARTOIS %~ IFP %~ CNRS %~ UNIV-LITTORAL %~ INRA %~ UCCS %~ INC-CNRS %~ AGREENIUM %~ UNIV-LILLE %~ INRAE %~ TEST-HALCNRS %~ ANR %~ TEST2-HALCNRS