The SW Alps are an active orogen undergoing intra-mountainous extension and peripheral compression. We discuss the significance of syn-orogenic extension based on a comparison of paleo-stress derived from faultslip data inversion reflecting the long-term (b12 Ma) evolution of SW Alps and the present-day stress state obtained by the inversion of the focal mechanisms of the last 30-years seismicity. The resulting stress states of long-term and active tectonic regimes are in good agreement, showing that extension accompanies strike-slip and reverse faulting in the southern part of the belt. The extensional deformation regime is limited to specific tectonic domains that can be interpreted as 'transitional' between pure strike-slip segments where the deformation concentrates on inherited ductile shear zones that were formed between 32° and 20 Ma ago. We thus propose that the extensional deformation in the SW Alps can be defined as a local deformation in a pull-apart type domain (High Durance - Jausiers area) or above slowly exhuming internal massifs (Dora Maira - Ivrea Body) along a curved boundary between the slowly rotating Apulian block and the relatively immobile Western Europe. The transcurrent fault system merges into a compressional front along the Mediterranean - Ligurian coast mainly to the east of San Remo.